Proteogenomic analysis of the total and surface-exposed proteomes of Plasmodium vivax salivary gland sporozoites

KE Swearingen; SE Lindner; EL Flannery; AM Vaughan; RD Morrison; R Patrapuvich; C Koepfli; I Muller; A Jex; RL Moritz; SHI Kappe; J Sattabongkot; SA Mikolajczak

Journal article

Proteogenomic analysis of the total and surface-exposed proteomes of Plasmodium vivax salivary gland sporozoites

KE Swearingen, SE Lindner, EL Flannery, AM Vaughan, RD Morrison, R Patrapuvich, C Koepfli, I Muller, A Jex, RL Moritz, SHI Kappe, J Sattabongkot, SA Mikolajczak

Plos Neglected Tropical Diseases | PUBLIC LIBRARY SCIENCE | Published : 2017

DOI: 10.1371/journal.pntd.0005791

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Abstract

Plasmodium falciparum and Plasmodium vivax cause the majority of human malaria cases. Research efforts predominantly focus on P. falciparum because of the clinical severity of infection and associated mortality rates. However, P. vivax malaria affects more people in a wider global range. Furthermore, unlike P. falciparum, P. vivax can persist in the liver as dormant hypnozoites that can be activated weeks to years after primary infection, causing relapse of symptomatic blood stages. This feature makes P. vivax unique and difficult to eliminate with the standard tools of vector control and treatment of symptomatic blood stage infection with antimalarial drugs. Infection by Plasmodium is initi..

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Aaron Jex Author

Ivo Mueller Author

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Awarded by National Health and Medical Research Council

Funding Acknowledgements

Research reported in this publication was supported by the Department of Defense under award number PR141672 (SAM, ELF, RP, JS), by the National Institutes of Health National Institute of Allergy and Infectious Disease (http://www.niaid.nih.gov/) under award numbers K25AI119229 (KES), 1K22AI101039 (SEL) and 1R01AI123341 (SEL), by the National Institutes of Health National Institute of General Medical Sciences (www.nigms.nih.gov) under award number P50GM076547 (RLM) and R01GM087221 (RLM), by the National Institutes of Health National Center for Research Resources under award number S10RR027584 (RLM), by the National Science Foundation (www.nsf.gov) under award number 0923536 (RLM, KES), by the National Health and Medical Research Council (https://www.nhmrc.gov.au/) under award numbers 1021544, 1043345, 1092789 (CK, IM, AJ) and 1126395 (AJ) and the Victorian State Government Operational Infrastructure Support and Australian Government National Health and Medical Research Council Independent Research Institute Infrastructure Support Scheme (CK, IM, AJ). The content is solely the responsibility of the authors and does not necessarily represent the official views of the Department of Defense, National Institutes of Health, the National Science Foundation, or the National Health and Medical Research Council. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.